Antihistamines - available either over the counter or by prescription - are a frequently recommended treatment for hives. They work by blocking the effect of histamine , a chemical in the skin that can cause allergy symptoms, including welts. Antihistamines that don't make you drowsy are preferred. Semaglutide (Ozempic) from the Point of View of Endocrinologist and Cardiologist: the Possibilities of Glucagon-like Peptide-1 Analogues are far from Exhausted.